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Proactiv 3 Step Acne Treatment

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    Overview of the highest quality evidence for the active ingredients in this product

    Webster GF, Sugarman J, Levy-Hacham O, Toledano O. Microencapsulated Benzoyl Peroxide and Tretinoin for the Treatment of Acne Vulgaris: Results from a Phase 2 Multicenter, Double-Blind, Randomized, Vehicle-Controlled Study. Skinmed. 2020.

    Gollnick, H. P., Draelos, Z., Glenn, M. J., Rosoph, L. A., Kaszuba, A., Cornelison, R., Gore, B., Liu, Y., Graeber, M., Adapalene, B. P. O. Study Group. Adapalene-benzoyl peroxide, a unique fixed-dose combination topical gel for the treatment of acne vulgaris: a transatlantic, randomized, double-blind, controlled study in 1670 patients. Br J Dermatol; 2009.

    Lookingbill, D. P., Chalker, D. K., Lindholm, J. S., et al. Treatment of acne with a combination clindamycin/benzoyl peroxide gel compared with clindamycin gel, benzoyl peroxide gel and vehicle gel: Combined results of two double-blind investigations. Journal of the American Academy of Dermatology. 1997;37(4):590-595.

    Eichenfield, L. F., Alio Saenz, A. B. Safety and efficacy of clindamycin phosphate 1.2%-benzoyl peroxide 3% fixed-dose combination gel for the treatment of acne vulgaris: a phase 3, multicenter, randomized, double-blind, active- and vehicle-controlled study. J Drugs Dermatol. 2011;10(12):1382-1396.

    Smith E.B, Padilla R.S, McCabe J.M, Becker L.E. Benzoyl peroxide lotion (20 percent) in acne. Cutis. 1980; 25: 90-92

    Chalker D.K, Shalita A, Smith J.G, Swann R.W. A double-blind study of the effectiveness of a 3% erythromycin and 5% benzoyl peroxide combination in the treatment of acne vulgaris.

    J Am Acad Dermatol. 1983; 9: 933-936

    Fyrand O, Jakobsen H.B. Water-based versus alcohol-based benzoyl peroxide preparations in the treatment of acne vulgaris. Dermatol. 1986; 172: 263-267

    Mills Jr., O.H, Kligman A.M, Pochi P, Comite H.

    Comparing 2.5%, 5%, and 10% benzoyl peroxide on inflammatory acne vulgaris.

    Int J Dermatol. 1986; 25: 664-667

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